Page 2 - Combined_11_OCR

2. Duncan, B., Scheel, L.D., Fairchild, E.J., Killens, R., Graham, S.: Am. Ind. Hyg.
Assn. J. 23, 447 (1962). I
3. Niewenhuis, R., Scheel, L.D., Stemmer, K., Killens, R.: Am. Ind. Hyg. Assn. J.
26, 143 (1965). ro > — »
Scheel, L.D., Killens, R., Josephson, A.: Am. Ind. Hyg. Assn. J. 25, 179 (1964).
Elkins, H.B.: Threshold Limits Committee Report, Mar. 1960.
Walworth, H.T., Virchow, W.E.: Am. Ind. Hyg.'Assn. J. 20., 205 (1959). -F* (J
Munn, A.: Trans. Assn. Ind. Med. Off., 9_, 134 (1960). •

o-TOLUIDINE - Skin
3
5 ppm (Approximately 22 rpg/m )

Smyth (1) found that rats were not killed by eight hours' inhalation of saturated
vapors of o-toluidine. Henderson and Haggard (2) state that its vapor toxicity is much
like that of aniline (slight symptoms after several hours at 6 to 23 ppm and 7 to 53
ppm respectively). Fairhall (3) also found the symptoms to be similar to those from
aniline.
A threshold limit of 5 ppm, the same as that for aniline, is recommended to pre­
vent systemic toxicity.

References:

1. Smyth, H.F., Jr..: Unpublished work by Chemical Hygiene Fellowship Mellon Institute
Pittsburgh (1937-55).
2. Henderson, Y., Haggard, H.W.: Noxious Gases, 2nd Ed., Reinhold Press, New York
(1943), p. 228.
Fairhall, L.T.: Industrial Toxicology, Williams and Wilkins, Baltimore (1949),
p. 450. C D

% Q) CO
X
1,1,2-TRICHLOROETHANE (vinyl trichloride) - Skin
□
10 ppm (Approximately 45 mg/m ) ? -u zr
m o j 13 Q
1,1,2-trichloroethane (vinyl tri’chloride) depresses the central nervous system
causing narcosis in which respect it is considerably more potent than chloroform (1,2). o
By inhalation it is somewhat more acutely toxic for certain laboratory animals (cats) q rr
than is chloroform. Narcotic concentrations of 1,1,2-trichloroethane result in irrita­ <
tion to the eyes and nose and injection of the conjunctiva. Death occurs from respiratory tn cu D
arrest. Concentrations producing deep narcosis and death are of the order of 13,600 C
ppm for a two-hour exposure; 30,000 ppm to 40,000 ppm is the corresponding concentration
for chloroform. 1,1,2-trichloroethane is lethal by oral and subcutaneous administration; Re
0.75 g/kg was lethal to the dog by mouth compared with 2.25 g/kg for chloroform (3);
fatty degeneration of the liver was observed in dogs dying two or more days post adminis­ 1.
tration of the tri chloroethane. 1,1,2-trichloroethane is absorbed throuqh the intact
skin (4). cxi co
i
Because of the great toxicologic resemblance of 1,1,2-trichloroethane to symmetric
tetrachloroethane and by analogy with the threshold limit value for chloroform, a limit lq to
of 10 ppm is recommended for 1,1,2-trichloroethane. The limit should be sufficiently low
to prevent Injury to the liver and provide freedom from irritation and narcosis by a
large margin. 7.

192